The Genealogy of a Sequence Subject to Purifying Selection at Multiple Sites
نویسندگان
چکیده
منابع مشابه
The genealogy of a sequence subject to purifying selection at multiple sites.
We investigate the effect of purifying selection at multiple sites on both the shape of the genealogy and the distribution of mutations on the tree. We find that the primary effect of purifying selection on a genealogy is to shift the distribution of mutations on the tree, whereas the shape of the tree remains largely unchanged. This result is relevant to the large number of coalescent estimati...
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15 صفحه اولDetecting amino acid sites under positive selection and purifying selection.
An excess of nonsynonymous over synonymous substitution at individual amino acid sites is an important indicator that positive selection has affected the evolution of a protein between the extant sequences under study and their most recent common ancestor. Several methods exist to detect the presence, and sometimes location, of positively selected sites in alignments of protein-coding sequences...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2002
ISSN: 1537-1719,0737-4038
DOI: 10.1093/oxfordjournals.molbev.a004199